Wednesday, March 20, 2024
8:00 AM - 1:15 PM CT

Register Now

The 2024 Advancements in GRID, LATTICE, Microbeam, and FLASH Symposium provides a review and update on the clinical practice, physics, and biology of novel non-homogenous radiation therapy, including spatially-fractionated therapy (SFRT), GRID, LATTICE, Microbeam, and FLASH radiotherapy. The program will be multidisciplinary, representing clinical practice, physics, and biology in each session; and will focus on the intersections of clinical application, biology, and physics, which are strongly interdependent. Current knowledge in all three disciplines will be critically appraised in each session and future perspectives will be developed for clinical research, physics, technological development, and basic science in these evolving fields. 

Learning Objectives:

Objective 1: Identify recent advancements in SFRT research and clinical application.

Objective 2:  Learn about recent advancements in FLASH research and clinical translation.

Objective 3:  Gain a current understanding of SFRT treatment planning methods.  

Agenda

Moderators:  Sha Chang, PhD, FAAPM, DABR, Lineberger Clinical Cancer Center of University of North Carolina, and College of Veterinary Medicine, NCSU University of North Carolina School of Medicine, Chapel Hill, NC and Christian Hyde, MD, DABR, Karmanos Cancer Institute, McLaren Proton Therapy, Wayne State University, Detroit, MI

8:00 - 8:05 a.m.    Introduction
Speaker:  Sha Chang, PhD, FAAPM, DABR, Lineberger Clinical Cancer Center of University of North Carolina, and College of Veterinary Medicine, NCSU University of North Carolina School of Medicine, Chapel Hill, NC

8:05 - 8:20 a.m.     Radio-Immune Response Modeling for Spatially Fractionated Radiotherapy
Speaker:  Young-Bin Cho, MD, PhD, Cleveland Clinic Lerner College of Medicine of Case Western University, Cleveland and Taussig Cancer Institute, Cleveland, OH

8:23 - 8:38 a.m.      Minibeam Radiotherapy is Superior to Conventional Radiotherapy When Combined with Immune Checkpoint Inhibition in a B16F10 Murine Melanoma Model
Speaker:  Michael Grams, PhD, Mayo Clinic, Rochester, MN

8:41 - 8:56 a.m.     Preclinical Proton SFRT Treatment Planning and Biology Study at University of Kansas           
Speaker:  Yuting Lin, PhD, University of Kansas School of Medicine, KS

8:59 - 9:14 a.m.     What We Learned on Partial Tumor Irradiation from Preclinical Studies
Speaker:  Adriana Haimovitz-Friedman, PhD, Memorial Sloan Kettering Cancer, New York, NY

9:17 - 9:32 a.m.     Randomized Study of Treating De-Novo Brain Tumors in Canines using Linac-based Microbeams
Speaker:  Vijayananda Kundapur, MD,DMRT, FRCR, Saskatoon Cancer Center, Saskatoon, Canada

9:35 - 9:50 a.m.     Exploring the Safety, Efficacy, and Mechanism of Action of GRID:  A Prospective Study of Patients with Extremity Sarcoma
Speaker:  Theodore Yanagilhara, MD, PhD, University of North Carolina, Chapel Hill, NC

10:03 -10:18 a.m.   Initial SFRT Experience in Treating Pediatric Bulky Tumor Patients
Speaker:  Kenneth Wong, MD, Keck School of Medicine of the USC, Los Angeles, CA

10:21 - 10:36 a.m.  Partial Irradiation Enhanced Immunotherapy
Speaker:  James Welsh, MD, MS, FACRO, Loyola University, Hines VA  Radiation Oncology, Hines, IL

10:39 - 10:54 a.m.  Temporally Fractionated Sub-Millimeter SFRT Boosts Anti-Tumor Immune Responses in Radioresistant Melanoma
Speaker:  Verdiana Trappetti, PhD - Institute of Anatomy, University of Bern Baltzerstrass, Bern, Switzerland

10:57 - 11:12 a.m.  The Impact of Temporal Fractionation of LATTICE Therapy in Clinical Practice
Speaker:  Beatriz Amendola, MD, FACR, FASTRO, FACRO; Innovative Cancer Center,  Miami, FL

11:15 -11:45 a.m.   Proton FLASH Preclinical Studies Using Small and Large Animals
Speaker:  Keith Cengel, MD, PhD, University of Pennsylvania, Philadelphia, PA

11:48 a.m. - 12:03 p.m.  Update on FLASH Clinical Trials
Speaker:  Charles B. Simone, II, MD, New York Proton Center and Memorial Sloan Kettering Cancer Center, New York, NY

12:06 – 12:20 p.m.  Panel Discussion on How Do We Streamline and Standardize Clinical SFRT     
Moderators:  J.W. Snider III, MD, South Florida Proton Therapy Institute, Delray Beach, FL, and Majid Mohiuddin, MD, Northwestern Chicago Proton Center, Warrenville, IL

12:30 - 1:10 p.m.     Lunchtime Presentation: Electron FLASH Radiation Therapy at Low Energy for the Treatment of Tumors up to 3 Cm Deep
Speaker:  Julie Colnot, PhD, Gustave Roussy Cancer Center, Paris

1:10-1:15 pm.       Closing Remarks
Speaker:  Christian Hyde, MD, DABR, Karmanos Cancer Institute, McLaren Proton Therapy, Wayne State University, Detroit, MI